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_the-flying-dutchman-by-roger-dane-bbc-radio-drama.webp "The Flying Dutchman<br/>SNT<br/>Author : Roger Danes<br/>Play : The Flying Dutchman<br/>First Broadcast on : 19 November 1994<br/><br/>For centuries, sailors around the world have told the legend of a cursed ghost ship, named The Flying Dutchman. The ship is cursed, and as such can never return to port. Since it has place to go, The Flying Dutchman sails around the ocean aimlessly, haunting the minds of sailors and toying with the imaginations of sea farers globally. There have been tales for ages, of late-night spotters in the crow's nest of a ship seeing a ghost ship passing their bow. Men swear on their lives that the cursed ship, The Flying Dutchman was seen sailing past them.<br/><br/>Where did this legend come from, and who started telling the story of this cursed ship? The first references to The Flying Dutchman comes from the writings of George Barrington in the late 1700's who wrote about the ship that appeared and then disappeared in a dark cloud - like an apparition. Several other writers and authors have written stories and poems including mentions of The Flying Dutchman. In all of the references, they talk about the ship being a terrible omen to sailors... They never want to see this ship. Seeing The Flying Dutchman is tantamount to a visit from God telling them that their voyage has been cursed. In such a circumstance a sailor must wonder if they will live to retirement age, let alone take a pension lump sum before retirement. At the point the Flying Dutchman is spotted retirement seems a long way off.<br/><br/>Was The Flying Dutchman an actual ship, or was it created as folklore? The jury is still out on this question, but many who have speculated about the legend agree that The Flying Dutchman was a ship that became doomed for one reason or another. Some say that The Flying Dutchman was used for piracy and was loaded with gold and other loot. While travelling with a load of treasure, unspeakable crimes were committed on board the ship, thus making it cursed forever.<br/><br/>Other variations of the legend say that the Captain of The Flying Dutchman refused to go to port in the face of a horrible storm and as a result the entire ship perished. Others claim that the ship was not called The Flying Dutchman - that instead it was the name of the captain of the ship. Eventually, as people passed the legend down through the generations, the story of The Flying Dutchman referred to the ship.<br/><br/>Throughout the years, many sailors have claimed to see a ship sailing past them, and then disappearing. One of the most famous men who swore to have seen The Flying Dutchman is Prince George of Wales, along with his brother Prince Albert Victor. In his writings, he stated that no less than thirteen men saw The Flying Dutchman sail by their ship in the middle of the night, and a few hours later disappeared from all site into thin air.<br/><br/>With all of these sightings, this leaves sailors and observers to wonder... Is there any merit to this legend? As has been well-documented, The Bermuda Triangle has")
_how-to-meet-girls-while-travelling.webp "iDateAdvice")
_how-to-approach-any-girl-in-public-without-being-creepy.webp "Coach Kyle")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn1.mypornvid.fun/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXR15HT9loyMcMP5zqJ-cK3tlAQN5v7P/(MyPornVid.fun)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_kim-kicks-girl-out-of-scott39s-suite-124-keeping-up-with-the-kardashians.webp "Hayu")
_bidens-executive-action-on-border-amp-trump-hesitates-on-declassifying-epstein-files-124-the-daily-show.webp "The Daily Show")
_-visit-the-hottest-place-in-the-world-seventy-degrees-loot-desert.webp "The hottest spot in the Lut Desert (Salt Desert) is called Gandom Beryan, which means \")
_travelling-essentials-with-names-124-travel-essentials-for-women-124-travel-packing.webp "THE GIRLY FASHION")
_9234girls-trips9234-should-we-trust-them.webp "Coach Corey Wayne")
_the-hottest-place-in-the-world-seventy-degrees-loot-desert-92.webp "The hottest place in the world (seventy degrees) Loot desert in Hindi/Urdu, Hot Place at Earth<br/>थाय विश्व में सबसे गर्म स्थान (सोंटे अट्ठाईस) हिंदी/उर्दू में लूट रेगिस्तान,<br/>دنیا کے گرم ترین مقام کا دورہ (ستر ڈگری) لوٹ صحرا<br/>The hottest spot in the Lut Desert (Salt Desert) is called Gandom Beryan, which means \")
_kuwtk-124-scott-disick-is-literally-under-fire-at-dinner-124-e.webp "E! Entertainment")
_school-board-meeting-6-4-24.webp "ACPS Video")
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